The Study on leakage of gas pipeline is to analyze and evaluate qualitatively and quantificationally the possible hazards. Based on FLUENT software established 3D leakage models with GAMBIT and simulated The leakage and release of sulfur natural gas pipeline at the state of 3D.The results show that the danger zone is greatly increased because of the presence of hydrogen sulfide simultaneously, at the condition of free diffusion. The leaked gas is mainly stayed at the upper of leak hole and has minor hazard zone, at the condition of wind. The hazard zone moved to downwind zone and gas gathered zone was formed but the direction of the wind had much less gas. Therefore, at the process of sulfur natural gas pipeline the hydrogen sulfide and wind lead to the increase of danger zone. 